Stem Cell Bioprocessing: For Cellular Therapy, Diagnostics and Drug Development (Woodhead Publishing Series in Biomedicine)

By Tiago G Fernandes, Maria Margarida Diogo

Stem cellphone bioprocessing describes the most large-scale bioprocessing concepts for either stem cellphone tradition and purification, envisaging the applying of those cells for regenerative drugs and drug screening. Bioreactor configurations are defined, together with their functions for stem phone enlargement, and stem cellphone separation innovations reminiscent of isolation and purification are mentioned. easy definitions are supplied about the types of stem cells, from grownup stem cells to the more moderen precipitated pluripotent stem cells. the most features of those assorted stem telephone varieties are defined, along the molecular mechanisms underlying their self-renewal and differentiation. The publication additionally specializes in methodologies presently used for in vitro stem cellphone tradition below static stipulations, together with the problem of xeno-free tradition stipulations, in addition to tradition parameters that impression stem mobile tradition. methods for either stem cellphone tradition and separation in micro-scale stipulations are provided, together with using mobile microarrays for high-throughput screening of the influence of either soluble and extracellular matrix molecules. yet another part is devoted to software of stem cells for regenerative medicine.

  • Maintains a different specialize in either the fundamental stem cellphone biology suggestions, and their translation to large-scale bioprocessing approaches
  • Envisages using stem cells in regenerative drugs and drug screening applications
  • Discusses the applying of microscale concepts as a device to accomplish easy stem telephone biology studies

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